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Dolutegravir-Related Neurological Adverse Events: A Case Report of Successful Management with Therapeutic Drug Monitoring

[ Vol. 13 , Issue. 1 ]

Author(s):

Francois Parant*, Patrick Miailhes, Florence Brunel and Marie-Claude Gagnieu   Pages 69 - 71 ( 3 )

Abstract:


Objective: Dolutegravir (DTG), a highly effective second-generation HIV integrase inhibitor with high genetic barrier to resistance, has shown excellent tolerability and safety profiles in clinical trials. However, some patients may experience neurological or psychiatric adverse effects leading to DTG discontinuation.

Case Report: This report describes a case of 29-year-old woman who developed neurological adverse events after starting the DTG-based antiretroviral therapy. Serum DTG concentrations were supratherapeutic which has required a dosing interval adjustment. The findings of this case report suggest that Therapeutic Drug Monitoring might be useful in individuals expressing unusual DTG pharmacokinetics.

Keywords:

Dolutegravir, antiretroviral, adverse events, pharmacokinetics, therapeutic drug monitoring, INSTI.

Affiliation:

Hospices Civils de Lyon - Laboratoire de Pharmacologie Toxicologie, Centre de Biologie, Sud. Lyon, Hospices Civils de Lyon - Laboratoire de Pharmacologie Toxicologie, Centre de Biologie, Sud. Lyon, Hospices Civils de Lyon - Laboratoire de Pharmacologie Toxicologie, Centre de Biologie, Sud. Lyon, Hospices Civils de Lyon - Laboratoire de Pharmacologie Toxicologie, Centre de Biologie, Sud. Lyon

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