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Teratogenic Effects of Third-generation Antiepileptic Drug, Pregabalin: An In vivo Study

[ Vol. 13 , Issue. 2 ]

Author(s):

Krishna Pal Singh* and Kiran Gupta   Pages 113 - 121 ( 9 )

Abstract:


Background: In the recent past, many third-generation antiepileptic drugs (AEDs) including Pregabalin (PGB) were launched for the treatment of diverse forms of epilepsy with better efficacy and safety profile than first-and-second-generation AEDs, but their teratogenic safety has not been established so far.

Objective: The present study has been undertaken to evaluate the reproductive and teratogenic potential (external and skeletal) of a novel and third generation AED, PGB in pregnant albino rats.

Methods: In this study, pregnant subjects were exposed to clinically relevant doses (41, 82 and 123 mg) of PGB from gestation days 6-20, and sacrificed on GD-21, and their fetuses were collected and examined to identify the birth defects and skeletal anomalies.

Results: This study revealed that prenatal exposure to PGB induced dose-dependent substantial fetal resorptions, litter size, fetal length and weight; and variety of minor external and internal malformations in fetuses predominant with limbs, tail, eyes, abdomen including hemorrhages, and poor skeletal ossification.

Conclusion: Thus, PGB was found to be teratogenic in rats at equivalent therapeutic doses, hence precaution should be taken before prescribing PGB to pregnant women with epilepsy.

Keywords:

Antiepileptic drugs, pregabalin, pregnancy, teratogenicity, birth defects, rat.

Affiliation:

Neurobiology Laboratory, Department of Zoology, University of Allahabad, Allahabad 211002, Neurobiology Laboratory, Department of Zoology, University of Allahabad, Allahabad 211002

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