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A Novel Desensitization Protocol for Infliximab Hypersensitivity in a 13-Year Old Patient with Pustular Psoriasis

[ Vol. 14 , Issue. 2 ]

Author(s):

Sapan Kumar Behera, Sandhiya Selvarajan*, Jerene Mathews, Chandana Shajil, Saibal Das, Malathi Munisamy and Alphienes Stanley Xavier   Pages 158 - 162 ( 5 )

Abstract:


Background: Drug hypersensitivity reactions to infliximab have been reported in pediatric patients. At times, these patients may need infliximab administration in spite of hypersensitivity. However, only a few reports of desensitization protocols are available in the literature in pediatric patients.

Case Report: We report a case of immediate hypersensitivity reaction to intravenous infliximab in a 13-year-old child suffering from pustular psoriasis who eventually underwent a 14 step desensitization protocol for the administration of infliximab in a pediatric intensive care unit.

Results and Conclusion: Although our desensitization protocol was safe and effective, we recommend the entire desensitization procedure to be performed under the supervision of experienced personnel in a pediatric intensive care unit. Future studies with larger sample size are needed to confirm our findings.

Keywords:

Desensitization, infliximab, monoclonal antibody, pediatric, psoriasis, BAT.

Affiliation:

Department of Clinical Pharmacology, Jawaharlal Institute of Postgraduate Medical Education and Research, (JIPMER), Puducherry, Department of Clinical Pharmacology, Jawaharlal Institute of Postgraduate Medical Education and Research, (JIPMER), Puducherry, Department of Dermatology & STD, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, Department of Dermatology & STD, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, Department of Clinical Pharmacology, Jawaharlal Institute of Postgraduate Medical Education and Research, (JIPMER), Puducherry, Department of Dermatology & STD, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, Department of Pharmacology, Sri Ramachandra Institute of Higher Education and Research, Chennai



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