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Treatment with Paracetamol is not Associated with Increased Airway Sensitivity and Risk of Asthma in Rats

[ Vol. 14 , Issue. 2 ]

Author(s):

Marco Túlio Lacerda Ribeiro, Hellen Karine Paes Porto, Daniel Fernandes de Oliveira, Patrícia Ferreira da Silva Castro and Matheus Lavorenti Rocha*   Pages 109 - 115 ( 7 )

Abstract:


Background: Some studies have linked the use of paracetamol (PAR) with adverse effects like wheezing, exacerbation of asthma symptoms and other respiratory problems. Other studies are inconclusive or deny this correlation. This makes the association between PAR and airway hypersensitivity very controversial and still under debate.

Objective: This work investigated if chronic treatment with PAR in rats could directly affect the contraction and relaxation for different stimulus in isolated airways.

Methods: Rats were treated for 2 weeks with PAR (400 mg/Kg, v.o.). The blood was collected for biochemical analysis (alanine aminotransferase (ALT), aspartate aminotransferase (AST), TBARs reaction and glutathione) and isolated tracheal rings were prepared in organ bath to measure isometric tone after contractile and relaxant stimulus.

Results: Hepatic enzymes (ALT, AST) and lipid peroxidation were increased after PAR-treatment, while glutathione was decreased. Rats do not present any alteration in airway myocytes responsiveness, either to contractile or relaxant stimulus (i.e. cholinergic agonist, membrane depolarization, Ca2+ influx across sarcolemma, internal Ca2+ release from sarcoplasmic reticulum, Ca2+ channel blocking, β-agonist and NOmediating relaxation).

Conclusion: Despite increased oxidative stress and reduced antioxidant defense, chronic treatment with PAR does not induce airway hypersensitivity or risk of asthma in rats.

Keywords:

Paracetamol, airways responsiveness, asthma, contraction, relaxation, ALT, AST, BAL.

Affiliation:

Faculty of Pharmacy, Federal University of Goias, Avenida Universitaria s/n, 74605-220, Goiania, Faculty of Pharmacy, Federal University of Goias, Avenida Universitaria s/n, 74605-220, Goiania, Clinical Laboratory, University Hospital, Federal University of Goias, 1ª Avenida, s/n, 74605-020, Goiania, Itumbiara Campus, State University of Goias, Avenida Modesto de Carvalho, s/n, Distrito Agoindustrial, Itumbiara 75536-100, Faculty of Pharmacy, Federal University of Goias, Avenida Universitaria s/n, 74605-220, Goiania

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