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Panitumumab Induced Forearm Panniculitis in Two Women With Metastatic Colon Cancer

[ Vol. 14 , Issue. 3 ]

Author(s):

Ciliberto Domenico, Ierardi Antonella, Caroleo Benedetto, Scalise Luigi, Cimellaro Antonio, Colangelo Lidia, Spaziano Giuseppe and Luca Gallelli *   Pages 233 - 237 ( 5 )

Abstract:


Background: Panitumumab is an EGFR inhibitor used for the treatment of metastatic colorectal cancer (mCRC), even if its use is related to skin toxicity.

Case Presentation: We report the development of forearm panniculitis in two women during the treatment with Panitumumab (6 mg/Kg intravenous every 2 weeks) + FOLFOX-6 (leucovorin, 5- fluorouracil, and oxaliplatin at higher dosage) for the treatment of mCRC.

Results: In both patients, clinical, laboratory and radiological evaluation documented the presence of a local panniculitis, probably related to panitumumab (Naranjo score: 6). Panatimumab discontinuation and antimicrobial + corticosteroid treatment induced a remission of skin manifestations.

Conclusion: We reported for the first time the development of panniculitis during Panitumumab treatment, and we documented that the treatment with beta-lactams to either fluoroquinolones or oxazolidinone in the presence of corticosteroid improves clinical symptoms in young patients with mCRC, without the development of adverse drug reactions or drug-drug interactions.

Keywords:

Panitumumab, panniculitis, adverse drug reaction, EGFR, mCRC, FOLFOX.

Affiliation:

Department of Medical Science, Oncology and Elderly Operative Units, Mater Domini Hospital, University of Catanzaro, Catanzaro, Department of Medical Science, Oncology and Elderly Operative Units, Mater Domini Hospital, University of Catanzaro, Catanzaro, Department of Medical Science, Oncology and Elderly Operative Units, Mater Domini Hospital, University of Catanzaro, Catanzaro, Department of Medical Science, Oncology and Elderly Operative Units, Mater Domini Hospital, University of Catanzaro, Catanzaro, Department of Medical Science, Oncology and Elderly Operative Units, Mater Domini Hospital, University of Catanzaro, Catanzaro, Department of Medical Science, Oncology and Elderly Operative Units, Mater Domini Hospital, University of Catanzaro, Catanzaro, Department of Experimental Medicine, University Vanvitelli of Naples, Naples, Department of Health Sciences, Clinical Pharmacology and Pharmacovigilance Unit, MaterDomini Hospital, University of Catanzaro, Catanzaro

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